The “Overthinker Gene” and Why Some Women Crash After Coffee or Wine
Jul 07, 2025
The “Overthinker Gene” and Why Some Women Crash After Coffee or Wine
The gene? COMT. The symptom? Mental noise, poor sleep, overstimulation, and wine-induced weepiness.
If you get anxious after wine, wired after coffee, or overstimulated after back-to-back social stuff, it might be your COMT gene saying, "Whoa there."
- Fast COMT: You burn through dopamine fast. You might feel restless or need more stimulation more often.
- Slow COMT: You hang onto stress longer. You’re more sensitive to pressure, people, and yes, pinot. I’m not raising my hand over here… (ok ok, I am. But this was a game changer for me to understand about my biology and know how to support my mind and body).
Neither is good or bad. But if you’re trying to optimize your focus, mood, or sleep — this gene is worth knowing.
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